Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection
Identifieur interne : 003481 ( Main/Exploration ); précédent : 003480; suivant : 003482Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection
Auteurs : H. Li [République populaire de Chine] ; N. L.-S. Tang [République populaire de Chine, Hong Kong] ; P. K.-S. Chan [Hong Kong] ; C.-Y. Wang [République populaire de Chine] ; D. S.-C. Hui [Hong Kong] ; C. Luk [Hong Kong] ; R. Kwok [Hong Kong] ; W. Huang [République populaire de Chine, Hong Kong] ; J. J.-Y. Sung [Hong Kong] ; Q.-P. Kong [République populaire de Chine] ; Y.-P. Zhang [République populaire de Chine]Source :
- Journal of medical genetics [ 0022-2593 ] ; 2008.
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Abstract
Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.
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Li</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N. 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Tang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K.-S." last="Chan">P. K.-S. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D. S.-C." last="Hui">D. S.-C. Hui</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Departments of Medicine &t Therapeutics, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Luk, C" sort="Luk, C" uniqKey="Luk C" first="C." last="Luk">C. Luk</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Kwok, R" sort="Kwok, R" uniqKey="Kwok R" first="R." last="Kwok">R. Kwok</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W." last="Huang">W. Huang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J.-Y." last="Sung">J. J.-Y. Sung</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q.-P." last="Kong">Q.-P. Kong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0510355</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0510355 INIST</idno><idno type="RBID">Pascal:08-0510355</idno><idno type="wicri:Area/PascalFrancis/Corpus">000247</idno><idno type="wicri:Area/PascalFrancis/Curation">000741</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000261</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000261</idno><idno type="wicri:doubleKey">0022-2593:2008:Li H:polymorphisms:in:the</idno><idno type="wicri:Area/Main/Merge">003587</idno><idno type="wicri:Area/Main/Curation">003481</idno><idno type="wicri:Area/Main/Exploration">003481</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection</title><author><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N. L.-S." last="Tang">N. L.-S. Tang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K.-S." last="Chan">P. K.-S. Chan</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Graduate University of the Chinese Academy of Sciences</s1><s2>Beijing</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D. S.-C." last="Hui">D. S.-C. Hui</name><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>Departments of Medicine &t Therapeutics, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>5 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Luk, C" sort="Luk, C" uniqKey="Luk C" first="C." last="Luk">C. Luk</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Kwok, R" sort="Kwok, R" uniqKey="Kwok R" first="R." last="Kwok">R. Kwok</name><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W." last="Huang">W. Huang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J.-Y." last="Sung">J. J.-Y. Sung</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Departments of Microbiology, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong</s1><s3>HKG</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Hong Kong</country><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q.-P." last="Kong">Q.-P. Kong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Laboratory for Conservation and Utilization of Bio-resource, Yunnan University</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Kunming</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</s1><s2>Kunming</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>KIZ/ CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of medical genetics</title><title level="j" type="abbreviated">J. med. genet.</title><idno type="ISSN">0022-2593</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of medical genetics</title><title level="j" type="abbreviated">J. med. genet.</title><idno type="ISSN">0022-2593</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome F19</term><term>Coronavirus</term><term>Gene cluster</term><term>Genetic determinism</term><term>Genetics</term><term>Human</term><term>Infection</term><term>Lectin</term><term>Pathogenesis</term><term>Polymorphism</term><term>Predisposition</term><term>Severe acute respiratory syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Infection</term><term>Polymorphisme</term><term>Lectine</term><term>Batterie gène</term><term>Chromosome F19</term><term>Pathogénie</term><term>Déterminisme génétique</term><term>Prédisposition</term><term>Syndrome respiratoire aigu sévère</term><term>Coronavirus</term><term>Génétique</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Polymorphisms of CLEC4M have been associated with predisposition for infection by the severe acute respiratory syndrome coronavirus (SARS-CoV). DC-SIGNR, a C-type lectin encoded by CLEC4M, is a receptor for the virus. A variable number tandem repeat (VNTR) polymorphism in its neck region was recently associated with susceptibility to SARS infection. However, this association was controversial and was not supported by subsequent studies. Two explanations may account for this discrepancy: (1) there may be an unknown predisposition polymorphism located in the proximity which is linked to the VNTR; or (2) it was a spurious association due to unrecognised population structure in the VNTR. Methods: We performed a comprehensively genetic association study on this C-type lectin gene cluster (FCER2, CLEC4G, CD209, and CLEC4M) at 19p13.3 by a tagging single nucleotide polymorphisms (SNPs) approach. Results: 23 tagSNPs were genotyped in 181 SARS patients and 172 population controls. No significant association with disease predisposition was detected. Genetic variations in this cluster also did not predict disease prognosis. However, we detected a population stratification of the VNTR alleles in a sample of 1145 Han Chinese collected from different parts of China. Conclusion: The results indicated that the genetic predisposition allele was not found in this lectin gene cluster and population stratification might cause the previous positive association.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name></noRegion><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W." last="Huang">W. Huang</name><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q.-P." last="Kong">Q.-P. Kong</name><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q.-P." last="Kong">Q.-P. Kong</name><name sortKey="Kong, Q P" sort="Kong, Q P" uniqKey="Kong Q" first="Q.-P." last="Kong">Q.-P. Kong</name><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name><name sortKey="Li, H" sort="Li, H" uniqKey="Li H" first="H." last="Li">H. Li</name><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N. L.-S." last="Tang">N. L.-S. Tang</name><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name><name sortKey="Wang, C Y" sort="Wang, C Y" uniqKey="Wang C" first="C.-Y." last="Wang">C.-Y. Wang</name><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name><name sortKey="Zhang, Y P" sort="Zhang, Y P" uniqKey="Zhang Y" first="Y.-P." last="Zhang">Y.-P. Zhang</name></country><country name="Hong Kong"><noRegion><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N. L.-S." last="Tang">N. L.-S. Tang</name></noRegion><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K.-S." last="Chan">P. K.-S. Chan</name><name sortKey="Chan, P K S" sort="Chan, P K S" uniqKey="Chan P" first="P. K.-S." last="Chan">P. K.-S. Chan</name><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W." last="Huang">W. Huang</name><name sortKey="Huang, W" sort="Huang, W" uniqKey="Huang W" first="W." last="Huang">W. Huang</name><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D. S.-C." last="Hui">D. S.-C. Hui</name><name sortKey="Hui, D S C" sort="Hui, D S C" uniqKey="Hui D" first="D. S.-C." last="Hui">D. S.-C. Hui</name><name sortKey="Kwok, R" sort="Kwok, R" uniqKey="Kwok R" first="R." last="Kwok">R. Kwok</name><name sortKey="Luk, C" sort="Luk, C" uniqKey="Luk C" first="C." last="Luk">C. Luk</name><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J.-Y." last="Sung">J. J.-Y. Sung</name><name sortKey="Sung, J J Y" sort="Sung, J J Y" uniqKey="Sung J" first="J. J.-Y." last="Sung">J. J.-Y. Sung</name><name sortKey="Tang, N L S" sort="Tang, N L S" uniqKey="Tang N" first="N. L.-S." last="Tang">N. L.-S. Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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